Gene: DBH-AS1

Alternate names for this Gene: NCRNA00118

Gene Summary:

Gene is located in Chromosome: 9

Location in Chromosome : 9q34.2

Description of this Gene: DBH antisense RNA 1

Type of Gene: ncRNA

Gene: DBH

Alternate names for this Gene: DBM|ORTHYP1

Gene Summary: The protein encoded by this gene is an oxidoreductase belonging to the copper type II, ascorbate-dependent monooxygenase family. The encoded protein, expressed in neuroscretory vesicles and chromaffin granules of the adrenal medulla, catalyzes the conversion of dopamine to norepinephrine, which functions as both a hormone and as the main neurotransmitter of the sympathetic nervous system. The enzyme encoded by this gene exists exists in both soluble and membrane-bound forms, depending on the absence or presence, respectively, of a signal peptide. Mutations in this gene cause dopamine beta-hydroxylate deficiency in human patients, characterized by deficits in autonomic and cardiovascular function, including hypotension and ptosis. Polymorphisms in this gene may play a role in a variety of psychiatric disorders.

Gene is located in Chromosome: 9

Location in Chromosome : 9q34.2

Description of this Gene: dopamine beta-hydroxylase

Type of Gene: protein-coding