Gene: DCN

Alternate names for this Gene: CSCD|DSPG2|PG40|PGII|PGS2|SLRR1B

Gene Summary: This gene encodes a member of the small leucine-rich proteoglycan family of proteins. Alternative splicing results in multiple transcript variants, at least one of which encodes a preproprotein that is proteolytically processed to generate the mature protein. This protein plays a role in collagen fibril assembly. Binding of this protein to multiple cell surface receptors mediates its role in tumor suppression, including a stimulatory effect on autophagy and inflammation and an inhibitory effect on angiogenesis and tumorigenesis. This gene and the related gene biglycan are thought to be the result of a gene duplication. Mutations in this gene are associated with congenital stromal corneal dystrophy in human patients.

Gene is located in Chromosome: 12

Location in Chromosome : 12q21.33

Description of this Gene: decorin

Type of Gene: protein-coding