Gene: DCSTAMP
Alternate names for this Gene: FIND|TM7SF4|hDC-STAMP
Gene Summary: This gene encodes a seven-pass transmembrane protein that is primarily expressed in dendritic cells. The encoded protein is involved in a range of immunological functions carried out by dendritic cells. This protein plays a role in osteoclastogenesis and myeloid differentiation. Alternate splicing results in multiple transcript variants.
Gene is located in Chromosome: 8
Location in Chromosome : 8q22.3
Description of this Gene: dendrocyte expressed seven transmembrane protein
Type of Gene: protein-coding
Gene: DPYS
Alternate names for this Gene: DHP|DHPase
Gene Summary: Dihydropyrimidinase catalyzes the conversion of 5,6-dihydrouracil to 3-ureidopropionate in pyrimidine metabolism. Dihydropyrimidinase is expressed at a high level in liver and kidney as a major 2.5-kb transcript and a minor 3.8-kb transcript. Defects in the DPYS gene are linked to dihydropyrimidinuria.
Gene is located in Chromosome: 8
Location in Chromosome : 8q22.3
Description of this Gene: dihydropyrimidinase
Type of Gene: protein-coding
rs2458413 in
DCSTAMP;DPYS gene and
Osteitis Deformans
PMID 21623375 2011 Our data also confirmed the association of TM7SF4 (rs2458413, OR = 1.40, P = 7.38 × 10(-17)) with PDB.
PMID 20436471 2010 Genome-wide association study identifies variants at CSF1, OPTN and TNFRSF11A as genetic risk factors for Paget's disease of bone.
rs2458413 in
DCSTAMP;DPYS gene and
Paget Disease
PMID 20436471 2010 Genome-wide association study identifies variants at CSF1, OPTN and TNFRSF11A as genetic risk factors for Paget's disease of bone.
PMID 21623375 2011 Genome-wide association identifies three new susceptibility loci for Paget's disease of bone.