Gene: DCTN5

Alternate names for this Gene: -

Gene Summary: This gene encodes a subunit of dynactin, a component of the cytoplasmic dynein motor machinery involved in minus-end-directed transport. The encoded protein is a component of the pointed-end subcomplex and is thought to bind membranous cargo. A pseudogene of this gene is located on the long arm of chromosome 1. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene.

Gene is located in Chromosome: 16

Location in Chromosome : 16p12.2

Description of this Gene: dynactin subunit 5

Type of Gene: protein-coding

Gene: PALB2

Alternate names for this Gene: FANCN|PNCA3

Gene Summary: This gene encodes a protein that may function in tumor suppression. This protein binds to and colocalizes with the breast cancer 2 early onset protein (BRCA2) in nuclear foci and likely permits the stable intranuclear localization and accumulation of BRCA2.

Gene is located in Chromosome: 16

Location in Chromosome : 16p12.2

Description of this Gene: partner and localizer of BRCA2

Type of Gene: protein-coding

rs515726118 in DCTN5;PALB2 gene and Malignant neoplasm of breast PMID 24136930 2013 The PALB2 gene is a strong candidate for clinical testing in BRCA1- and BRCA2-negative hereditary breast cancer.

PMID 17200668 2007 PALB2, which encodes a BRCA2-interacting protein, is a breast cancer susceptibility gene.

PMID 25099575 2014 Breast-cancer risk in families with mutations in PALB2.

rs515726118 in DCTN5;PALB2 gene and Neoplastic Syndromes, Hereditary PMID 21618343 2011 Germline mutations in the PALB2 gene are population specific and occur with low frequencies in familial breast cancer.