Gene: DDN-AS1

Alternate names for this Gene: CAT1507

Gene Summary:

Gene is located in Chromosome: 12

Location in Chromosome : 12q13.12

Description of this Gene: DDN and PRKAG1 antisense RNA 1

Type of Gene: ncRNA

Gene: PRKAG1

Alternate names for this Gene: AMPKG

Gene Summary: The protein encoded by this gene is a regulatory subunit of the AMP-activated protein kinase (AMPK). AMPK is a heterotrimer consisting of an alpha catalytic subunit, and non-catalytic beta and gamma subunits. AMPK is an important energy-sensing enzyme that monitors cellular energy status. In response to cellular metabolic stresses, AMPK is activated, and thus phosphorylates and inactivates acetyl-CoA carboxylase (ACC) and beta-hydroxy beta-methylglutaryl-CoA reductase (HMGCR), key enzymes involved in regulating de novo biosynthesis of fatty acid and cholesterol. This subunit is one of the gamma regulatory subunits of AMPK. Alternatively spliced transcript variants encoding distinct isoforms have been observed.

Gene is located in Chromosome: 12

Location in Chromosome : 12q13.12

Description of this Gene: protein kinase AMP-activated non-catalytic subunit gamma 1

Type of Gene: protein-coding

rs2117029 in DDN-AS1;PRKAG1 gene and Intelligence PMID 29326435 2019 A combined analysis of genetically correlated traits identifies 187 loci and a role for neurogenesis and myelination in intelligence.