Gene: DDRGK1

Alternate names for this Gene: C20orf116|SEMDSH|UFBP1|dJ1187M17.3

Gene Summary: The protein encoded by this gene interacts with components of the ubiquitin fold modifier 1 conjugation pathway and helps prevent apoptosis in ER-stressed secretory tissues. In addition, the encoded protein regulates nuclear factor-κB activity.

Gene is located in Chromosome: 20

Location in Chromosome : 20p13

Description of this Gene: DDRGK domain containing 1

Type of Gene: protein-coding

rs11697186 in DDRGK1 gene and Hepatitis C, Chronic PMID 21659334 2011 Genome-wide association study identified ITPA/DDRGK1 variants reflecting thrombocytopenia in pegylated interferon and ribavirin therapy for chronic hepatitis C.