Gene: DEFB121

Alternate names for this Gene: DEFB21|ESC42RELC

Gene Summary: This gene encodes a member of the beta subfamily of defensins. Beta-defensins are antimicrobial peptides that protect tissues and organs from infection by a variety of microorganisms. This gene is found in a cluster with other beta-defensin genes on the long arm of chromosome 20. Two transcript variants encoding different isoforms have been found for this gene.

Gene is located in Chromosome: 20

Location in Chromosome : 20q11.21

Description of this Gene: defensin beta 121

Type of Gene: protein-coding

rs2376549 in DEFB121 gene and Stomach Carcinoma PMID 30281874 2018 Genome-wide association study identifies gastric cancer susceptibility loci at 12q24.11-12 and 20q11.21.