Gene: DELEC1

Alternate names for this Gene: CTS9|DEC1

Gene Summary: The function of this gene is not known. This gene is located in a region commonly deleted in esophageal squamous cell carcinomas. Gene expression is reduced or absent in these carcinomas and thus this is a candidate tumor suppressor gene for esophageal squamous cell carcinomas.

Gene is located in Chromosome: 9

Location in Chromosome : 9q33.1

Description of this Gene: deleted in esophageal cancer 1

Type of Gene: ncRNA

Gene: TNC

Alternate names for this Gene: 150-225|DFNA56|GMEM|GP|HXB|JI|TN|TN-C

Gene Summary: This gene encodes an extracellular matrix protein with a spatially and temporally restricted tissue distribution. This protein is homohexameric with disulfide-linked subunits, and contains multiple EGF-like and fibronectin type-III domains. It is implicated in guidance of migrating neurons as well as axons during development, synaptic plasticity, and neuronal regeneration.

Gene is located in Chromosome: 9

Location in Chromosome : 9q33.1

Description of this Gene: tenascin C

Type of Gene: protein-coding

rs3833490 in DELEC1;TNC gene and Blood Protein Measurement PMID 29875488 2018 Genomic atlas of the human plasma proteome.

rs137933052 in DELEC1;TNC gene and DEAFNESS, AUTOSOMAL DOMINANT 56 PMID 23936043 2013 Exome sequencing and linkage analysis identified tenascin-C (TNC) as a novel causative gene in nonsyndromic hearing loss.

rs1330349 in DELEC1;TNC gene and Osteoarthritis of hip PMID 30664745 2019 Identification of new therapeutic targets for osteoarthritis through genome-wide analyses of UK Biobank data.