Gene: DENND4A

Alternate names for this Gene: IRLB|MYCPBP

Gene Summary: This gene encodes a DENN domain-containing protein that may function as a guanine nucleotide exchange factor that specifically activates ras-related protein Rab-10. This protein also contains a interferon stimulated response element-binding domain and may be involved in regulating the v-myc avian myelocytomatosis viral (MYC) oncogene. Alternate splicing results in multiple transcript variants. A pseudogene of this gene is found on chromosome 8.

Gene is located in Chromosome: 15

Location in Chromosome : 15q22.31

Description of this Gene: DENN domain containing 4A

Type of Gene: protein-coding

Gene: RAB11A

Alternate names for this Gene: YL8

Gene Summary: The protein encoded by this gene belongs to the Rab family of the small GTPase superfamily. It is associated with both constitutive and regulated secretory pathways, and may be involved in protein transport. Two transcript variants encoding different isoforms have been found for this gene.

Gene is located in Chromosome: 15

Location in Chromosome : 15q22.31

Description of this Gene: RAB11A, member RAS oncogene family

Type of Gene: protein-coding

rs77559483 in DENND4A;RAB11A gene and Blood Protein Measurement PMID 29875488 2018 Genomic atlas of the human plasma proteome.

rs12899850 in DENND4A;RAB11A gene and Body mass index PMID 30108127 2018 A Large Multiethnic Genome-Wide Association Study of Adult Body Mass Index Identifies Novel Loci.

rs10431765 in DENND4A;RAB11A gene and Corpuscular Hemoglobin Concentration Mean PMID 23222517 2012 Seventy-five genetic loci influencing the human red blood cell.

rs2572207 in DENND4A;RAB11A gene and Finding of Mean Corpuscular Hemoglobin PMID 28017375 2017 Genome-wide Trans-ethnic Meta-analysis Identifies Seven Genetic Loci Influencing Erythrocyte Traits and a Role for RBPMS in Erythropoiesis.

PMID 27863252 2016 The Allelic Landscape of Human Blood Cell Trait Variation and Links to Common Complex Disease.

PMID 22560525 2012 Genetic Loci implicated in erythroid differentiation and cell cycle regulation are associated with red blood cell traits.

PMID 20139978 2010 Genome-wide association study of hematological and biochemical traits in a Japanese population.

rs6494537 in DENND4A;RAB11A gene and Hemoglobin measurement PMID 20139978 2010 Genome-wide association study of hematological and biochemical traits in a Japanese population.

rs2414884 in DENND4A;RAB11A gene and Mean Corpuscular Volume (result) PMID 27863252 2016 The Allelic Landscape of Human Blood Cell Trait Variation and Links to Common Complex Disease.

PMID 23222517 2012 Seventy-five genetic loci influencing the human red blood cell.

rs61751117 in DENND4A;RAB11A gene and Memory performance PMID 29274321 2018 Genome-wide association study of Alzheimer's disease endophenotypes at prediagnosis stages.