Gene: DGKK

Alternate names for this Gene: -

Gene Summary: The protein encoded by this gene is an enzyme that phosphorylates diacylglycerol, converting it to phosphatidic acid. The encoded protein is a membrane protein and is inhibited by hydrogen peroxide. Variations in this gene have been associated with hypospadias.

Gene is located in Chromosome: X

Location in Chromosome : Xp11.22

Description of this Gene: diacylglycerol kinase kappa

Type of Gene: protein-coding

rs1934179 in DGKK gene and Hypospadias PMID 21113153 2011 Common variants in DGKK are strongly associated with risk of hypospadias.

PMID 25108383 2014 Genome-wide association analyses identify variants in developmental genes associated with hypospadias.

rs140659849 in DGKK gene and Prostate carcinoma PMID 26307654 2015 Genome-wide association study of prostate cancer-specific survival.