Gene: DLG2

Alternate names for this Gene: PPP1R58|PSD-93|PSD93|chapsyn-110

Gene Summary: This gene encodes a member of the membrane-associated guanylate kinase (MAGUK) family. The encoded protein forms a heterodimer with a related family member that may interact at postsynaptic sites to form a multimeric scaffold for the clustering of receptors, ion channels, and associated signaling proteins. Multiple transcript variants encoding different isoforms have been found for this gene. Additional transcript variants have been described, but their full-length nature is not known.

Gene is located in Chromosome: 11

Location in Chromosome : 11q14.1

Description of this Gene: discs large MAGUK scaffold protein 2

Type of Gene: protein-coding

rs11823251 in DLG2 gene and Age at menarche PMID 30595370 2019 Leveraging Polygenic Functional Enrichment to Improve GWAS Power.

rs286028 in DLG2 gene and Body Weight PMID 28552196 2017 Whole-Genome Sequencing Coupled to Imputation Discovers Genetic Signals for Anthropometric Traits.

rs142615018 in DLG2 gene and Body mass index PMID 28552196 2017 Whole-Genome Sequencing Coupled to Imputation Discovers Genetic Signals for Anthropometric Traits.

PMID 30239722 2019 Meta-analysis of genome-wide association studies for body fat distribution in 694 649 individuals of European ancestry.

PMID 30595370 2019 Leveraging Polygenic Functional Enrichment to Improve GWAS Power.

rs1155311 in DLG2 gene and Cardiovascular Diseases PMID 30595370 2019 Leveraging Polygenic Functional Enrichment to Improve GWAS Power.

rs286499 in DLG2 gene and Chronic Obstructive Airway Disease PMID 25584925 2015 A genome-wide association study of chronic obstructive pulmonary disease in Hispanics.

rs655484 in DLG2 gene and Common Migraine PMID 28952330 2018 Genome-wide association study identifies novel susceptibility loci for migraine in Han Chinese resided in Taiwan.

rs17807909 in DLG2 gene and Influenza due to Influenza A virus subtype H1N1 PMID 26379185 2015 No Major Host Genetic Risk Factor Contributed to A(H1N1)2009 Influenza Severity.

rs2155413 in DLG2 gene and Myopia PMID 27182965 2016 Detection and interpretation of shared genetic influences on 42 human traits.

rs790356 in DLG2 gene and Nephroblastoma PMID 22544364 2012 A genome-wide association study identifies susceptibility loci for Wilms tumor.

rs3793947 in DLG2 gene and Parkinson Disease PMID 25064009 2014 Large-scale meta-analysis of genome-wide association data identifies six new risk loci for Parkinson's disease.

PMID 28892059 2017 A meta-analysis of genome-wide association studies identifies 17 new Parkinson's disease risk loci.

PMID 28011712 2017 Genome-wide association study of Parkinson's disease in East Asians.

rs17148090 in DLG2 gene and Phospholipid measurement PMID 22359512 2012 Genome-wide association study identifies novel loci associated with circulating phospho- and sphingolipid concentrations.

rs117214796 in DLG2 gene and Rheumatoid Arthritis PMID 30166627 2018 Genome-wide association study of response to tumour necrosis factor inhibitor therapy in rheumatoid arthritis.

rs1864774 in DLG2 gene and Schizophrenia PMID 28991256 2017 Genome-wide association analysis identifies 30 new susceptibility loci for schizophrenia.

PMID 26198764 2015 Genome-wide association study of schizophrenia in Ashkenazi Jews.

PMID 30285260 2019 Genome-Wide Association Study Detected Novel Susceptibility Genes for Schizophrenia and Shared Trans-Populations/Diseases Genetic Effect.

rs536665 in DLG2 gene and Waist-Hip Ratio PMID 30239722 2019 Meta-analysis of genome-wide association studies for body fat distribution in 694 649 individuals of European ancestry.

rs116875887 in DLG2 gene and mathematical ability PMID 30038396 2018 Gene discovery and polygenic prediction from a genome-wide association study of educational attainment in 1.1 million individuals.

rs150829342 in DLG2 gene and response to bronchodilator PMID 26634245 2015 A genome-wide association study identifies risk loci for spirometric measures among smokers of European and African ancestry.