Gene: DLL4

Alternate names for this Gene: AOS6|delta4|hdelta2

Gene Summary: This gene is a homolog of the Drosophila delta gene. The delta gene family encodes Notch ligands that are characterized by a DSL domain, EGF repeats, and a transmembrane domain.

Gene is located in Chromosome: 15

Location in Chromosome : 15q15.1

Description of this Gene: delta like canonical Notch ligand 4

Type of Gene: protein-coding

rs1247027543 in DLL4 gene and ADAMS-OLIVER SYNDROME 6 PMID 29924900 2018 Elucidating the genetic architecture of Adams-Oliver syndrome in a large European cohort.

PMID 26299364 2015 Heterozygous Loss-of-Function Mutations in DLL4 Cause Adams-Oliver Syndrome.

rs61750844 in DLL4 gene and Adams Oliver syndrome PMID 26299364 2015 Heterozygous Loss-of-Function Mutations in DLL4 Cause Adams-Oliver Syndrome.

rs12441495 in DLL4 gene and Intelligence PMID 29844566 2018 Study of 300,486 individuals identifies 148 independent genetic loci influencing general cognitive function.

PMID 29326435 2019 A combined analysis of genetically correlated traits identifies 187 loci and a role for neurogenesis and myelination in intelligence.

PMID 29942086 2018 Genome-wide association meta-analysis in 269,867 individuals identifies new genetic and functional links to intelligence.

rs1555393172 in DLL4 gene and Multiple congenital anomalies PMID 15466159 2004 Dosage-sensitive requirement for mouse Dll4 in artery development.

PMID 10837024 2000 Dll4, a novel Notch ligand expressed in arterial endothelium.

PMID 12482957 2003 Regulation of Notch1 and Dll4 by vascular endothelial growth factor in arterial endothelial cells: implications for modulating arteriogenesis and angiogenesis.

PMID 15817497 2005 Notch signaling, brain development, and human disease.

PMID 11585794 2001 Notch signaling is required for arterial-venous differentiation during embryonic vascular development.

PMID 12574630 2003 Angiogenesis-independent endothelial protection of liver: role of VEGFR-1.

PMID 15520367 2004 Haploinsufficiency of delta-like 4 ligand results in embryonic lethality due to major defects in arterial and vascular development.

PMID 17336907 2007 Notch signaling is essential for ventricular chamber development.

PMID 10221902 1999 Notch signaling: cell fate control and signal integration in development.

PMID 20976243 2010 Characterising and predicting haploinsufficiency in the human genome.

PMID 20147986 2010 Chronic DLL4 blockade induces vascular neoplasms.

PMID 17311993 2007 Inhibition of Dll4-mediated signaling induces proliferation of immature vessels and results in poor tissue perfusion.

PMID 17728344 2007 A regulatory network involving Foxn4, Mash1 and delta-like 4/Notch1 generates V2a and V2b spinal interneurons from a common progenitor pool.

PMID 21092311 2010 Combination of Dll4/Notch and Ephrin-B2/EphB4 targeted therapy is highly effective in disrupting tumor angiogenesis.

PMID 8756291 1996 The intracellular deletions of Delta and Serrate define dominant negative forms of the Drosophila Notch ligands.

PMID 8794055 1996 Neurogenic genes and vertebrate neurogenesis.

PMID 15923152 2005 Expression of Dll4 during mouse embryogenesis suggests multiple developmental roles.

PMID 15466160 2004 Haploinsufficient lethality and formation of arteriovenous malformations in Notch pathway mutants.

PMID 23570941 2013 Notch signaling in the brain: in good and bad times.

PMID 16773578 2006 NOTCH2 mutations cause Alagille syndrome, a heterogeneous disorder of the notch signaling pathway.

PMID 19369401 2009 Notch signaling controls liver development by regulating biliary differentiation.

PMID 17296941 2007 The Notch ligand Delta-like 4 negatively regulates endothelial tip cell formation and vessel branching.