Gene: DLST

Alternate names for this Gene: DLTS|KGD2|PGL7

Gene Summary: This gene encodes a mitochondrial protein that belongs to the 2-oxoacid dehydrogenase family. This protein is one of the three components (the E2 component) of the 2-oxoglutarate dehydrogenase complex that catalyzes the overall conversion of 2-oxoglutarate to succinyl-CoA and CO(2). Alternatively spliced transcript variants have been found for this gene.

Gene is located in Chromosome: 14

Location in Chromosome : 14q24.3

Description of this Gene: dihydrolipoamide S-succinyltransferase

Type of Gene: protein-coding

rs28426374 in DLST gene and Anxiety PMID 29942085 2018 Meta-analysis of genome-wide association studies for neuroticism in 449,484 individuals identifies novel genetic loci and pathways.

rs17093914 in DLST gene and Leukemia, Myelocytic, Acute PMID 27903959 2017 Genome-wide haplotype association study identify the FGFR2 gene as a risk gene for acute myeloid leukemia.

rs17093914 in DLST gene and Nervousness PMID 29500382 2018 Item-level analyses reveal genetic heterogeneity in neuroticism.