Gene: EGFR

Alternate names for this Gene: ERBB|ERBB1|HER1|NISBD2|PIG61|mENA

Gene Summary: The protein encoded by this gene is a transmembrane glycoprotein that is a member of the protein kinase superfamily. This protein is a receptor for members of the epidermal growth factor family. EGFR is a cell surface protein that binds to epidermal growth factor, thus inducing receptor dimerization and tyrosine autophosphorylation leading to cell proliferation. Mutations in this gene are associated with lung cancer. EGFR is a component of the cytokine storm which contributes to a severe form of Coronavirus Disease 2019 (COVID-19) resulting from infection with severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2).

Gene is located in Chromosome: 7

Location in Chromosome : 7p11.2

Description of this Gene: epidermal growth factor receptor

Type of Gene: protein-coding

Gene: EGFR-AS1

Alternate names for this Gene:

Gene Summary:

Gene is located in Chromosome:

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Description of this Gene:

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rs121913465 in EGFR;EGFR-AS1 gene and Esophageal carcinoma PMID 16707764 2006 Gefitinib-sensitizing mutations in esophageal carcinoma.

PMID 25157968 2014 Prospective enterprise-level molecular genotyping of a cohort of cancer patients.

rs121913465 in EGFR;EGFR-AS1 gene and Non-Small Cell Lung Carcinoma PMID 15623594 2004 High frequency of epidermal growth factor receptor mutations with complex patterns in non-small cell lung cancers related to gefitinib responsiveness in Taiwan.

PMID 19536777 2010 Second-line treatments after first-line gefitinib therapy in advanced nonsmall cell lung cancer.

PMID 16205628 2006 Distinctive activation patterns in constitutively active and gefitinib-sensitive EGFR mutants.

PMID 16863509 2006 EGFR point mutation in non-small cell lung cancer is occasionally accompanied by a second mutation or amplification.

PMID 25157968 2014 Prospective enterprise-level molecular genotyping of a cohort of cancer patients.

PMID 19147750 2009 Functional analysis of epidermal growth factor receptor (EGFR) mutations and potential implications for EGFR targeted therapy.

PMID 17653080 2008 EGFR mutants found in non-small cell lung cancer show different levels of sensitivity to suppression of Src: implications in targeting therapy.

PMID 20522446 2010 We reported a case of non-small cell lung cancer harboring a rare epidermal growth factor somatic mutation, codon 768 AGC > ATC in exon 20 (S768I), who showed a good clinical response to gefitinib.

PMID 16187797 2005 Oncogenic transformation by inhibitor-sensitive and -resistant EGFR mutants.

PMID 20422446 2010 Comparing ICA-based and single-trial topographic ERP analyses.

PMID 17045698 2006 Non-responsiveness to gefitinib in a patient with lung adenocarcinoma having rare EGFR mutations S768I and V769L.

PMID 18676761 2008 Lung cancer with epidermal growth factor receptor exon 20 mutations is associated with poor gefitinib treatment response.

rs121913230 in EGFR;EGFR-AS1 gene and Squamous cell carcinoma PMID 25157968 2014 Prospective enterprise-level molecular genotyping of a cohort of cancer patients.

rs121913465 in EGFR;EGFR-AS1 gene and Squamous cell carcinoma of lung PMID 22753918 2012 Randomized phase II study of dacomitinib (PF-00299804), an irreversible pan-human epidermal growth factor receptor inhibitor, versus erlotinib in patients with advanced non-small-cell lung cancer.

PMID 23102728 2013 MEK inhibitors reverse resistance in epidermal growth factor receptor mutation lung cancer cells with acquired resistance to gefitinib.