Gene: ENPEP

Alternate names for this Gene: APA|CD249|gp160

Gene Summary: The ENPEP gene encodes glutamyl aminopeptidase, a type II integral membrane protein with an extracellular zinc-binding domain. This protein can upregulate blood pressure by cleaving the N-terminal aspartate from angiotensin II, and can regulate blood vessel formation and enhance tumorigenesis in some tissues. Along with ANPEP and DPP4, ENPEP was found to be a candidate co-receptor for the coronavirus SARS-CoV-2, which causes COVID-19.

Gene is located in Chromosome: 4

Location in Chromosome : 4q25

Description of this Gene: glutamyl aminopeptidase

Type of Gene: protein-coding

Gene: ZNF969P

Alternate names for this Gene:

Gene Summary:

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rs6533515 in ENPEP;ZNF969P gene and Systolic Pressure PMID 30595370 2019 Leveraging Polygenic Functional Enrichment to Improve GWAS Power.

PMID 30578418 2019 Trans-ethnic association study of blood pressure determinants in over 750,000 individuals.