Gene: ENTPD4

Alternate names for this Gene: LALP70|LAP70|LYSAL1|NTPDase-4|UDPase

Gene Summary: This gene encodes a member of the apyrase protein family. Apyrases are enzymes that catalyze the hydrolysis of nucleotide diphosphates and triphosphates in a calcium or magnesium-dependent manner. The encoded protein is an endo-apyrase and may play a role in salvaging nucleotides from lysosomes. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene, and these isoforms may differ in divalent cation dependence and substrate specificity.

Gene is located in Chromosome: 8

Location in Chromosome : 8p21.3

Description of this Gene: ectonucleoside triphosphate diphosphohydrolase 4

Type of Gene: protein-coding

Gene: LOXL2

Alternate names for this Gene: LOR|LOR2|WS9-14

Gene Summary: This gene encodes a member of the lysyl oxidase gene family. The prototypic member of the family is essential to the biogenesis of connective tissue, encoding an extracellular copper-dependent amine oxidase that catalyses the first step in the formation of crosslinks in collagens and elastin. A highly conserved amino acid sequence at the C-terminus end appears to be sufficient for amine oxidase activity, suggesting that each family member may retain this function. The N-terminus is poorly conserved and may impart additional roles in developmental regulation, senescence, tumor suppression, cell growth control, and chemotaxis to each member of the family.

Gene is located in Chromosome: 8

Location in Chromosome : 8p21.3

Description of this Gene: lysyl oxidase like 2

Type of Gene: protein-coding