Gene: EP300
Alternate names for this Gene: KAT3B|MKHK2|RSTS2|p300
Gene Summary: This gene encodes the adenovirus E1A-associated cellular p300 transcriptional co-activator protein. It functions as histone acetyltransferase that regulates transcription via chromatin remodeling and is important in the processes of cell proliferation and differentiation. It mediates cAMP-gene regulation by binding specifically to phosphorylated CREB protein. This gene has also been identified as a co-activator of HIF1A (hypoxia-inducible factor 1 alpha), and thus plays a role in the stimulation of hypoxia-induced genes such as VEGF. Defects in this gene are a cause of Rubinstein-Taybi syndrome and may also play a role in epithelial cancer.
Gene is located in Chromosome: 22
Location in Chromosome : 22q13.2
Description of this Gene: E1A binding protein p300
Type of Gene: protein-coding
Gene: EP300-AS1
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