Gene: EPDR1

Alternate names for this Gene: EPDR|MERP-1|MERP1|UCC1

Gene Summary: The protein encoded by this gene is a type II transmembrane protein that is similar to two families of cell adhesion molecules, the protocadherins and ependymins. This protein may play a role in calcium-dependent cell adhesion. This protein is glycosylated, and the orthologous mouse protein is localized to the lysosome. Alternative splicing results in multiple transcript variants. A related pseudogene has been identified on chromosome 8.

Gene is located in Chromosome: 7

Location in Chromosome : 7p14.1

Description of this Gene: ependymin related 1

Type of Gene: protein-coding

Gene: SFRP4

Alternate names for this Gene: FRP-4|FRPHE|FRZB-2|PYL|sFRP-4

Gene Summary: Secreted frizzled-related protein 4 (SFRP4) is a member of the SFRP family that contains a cysteine-rich domain homologous to the putative Wnt-binding site of Frizzled proteins. SFRPs act as soluble modulators of Wnt signaling. The expression of SFRP4 in ventricular myocardium correlates with apoptosis related gene expression.

Gene is located in Chromosome: 7

Location in Chromosome : 7p14.1

Description of this Gene: secreted frizzled related protein 4

Type of Gene: protein-coding

rs75474297 in EPDR1;SFRP4 gene and Blood Protein Measurement PMID 30072576 2018 Co-regulatory networks of human serum proteins link genetics to disease.

rs1124268 in EPDR1;SFRP4 gene and Bone Density PMID 29304378 2018 Life-Course Genome-wide Association Study Meta-analysis of Total Body BMD and Assessment of Age-Specific Effects.

rs16879765 in EPDR1;SFRP4 gene and Dupuytren Contracture PMID 28886342 2017 A Genome-wide Association Study of Dupuytren Disease Reveals 17 Additional Variants Implicated in Fibrosis.

PMID 21732829 2011 Wnt signaling and Dupuytren's disease.

rs16879765 in EPDR1;SFRP4 gene and Dupuytren's Disease PMID 21732829 2011 Wnt signaling and Dupuytren's disease.

rs3816415 in EPDR1;SFRP4 gene and Primary angle-closure glaucoma PMID 27064256 2016 Genome-wide association study identifies five new susceptibility loci for primary angle closure glaucoma.