Gene: EPHB4

Alternate names for this Gene: CMAVM2|HFASD|HTK|LMPHM7|MYK1|TYRO11

Gene Summary: Ephrin receptors and their ligands, the ephrins, mediate numerous developmental processes, particularly in the nervous system. Based on their structures and sequence relationships, ephrins are divided into the ephrin-A (EFNA) class, which are anchored to the membrane by a glycosylphosphatidylinositol linkage, and the ephrin-B (EFNB) class, which are transmembrane proteins. The Eph family of receptors are divided into 2 groups based on the similarity of their extracellular domain sequences and their affinities for binding ephrin-A and ephrin-B ligands. Ephrin receptors make up the largest subgroup of the receptor tyrosine kinase (RTK) family. The protein encoded by this gene binds to ephrin-B2 and plays an essential role in vascular development.

Gene is located in Chromosome: 7

Location in Chromosome : 7q22.1

Description of this Gene: EPH receptor B4

Type of Gene: protein-coding

Gene: SLC12A9

Alternate names for this Gene: CCC6|CIP1|WO3.3|hCCC6

Gene Summary:

Gene is located in Chromosome: 7

Location in Chromosome : 7q22.1

Description of this Gene: solute carrier family 12 member 9

Type of Gene: protein-coding

rs314313 in EPHB4;SLC12A9 gene and Crohn Disease PMID 26192919 2015 Association analyses identify 38 susceptibility loci for inflammatory bowel disease and highlight shared genetic risk across populations.

rs314313 in EPHB4;SLC12A9 gene and Inflammatory Bowel Diseases PMID 26192919 2015 Association analyses identify 38 susceptibility loci for inflammatory bowel disease and highlight shared genetic risk across populations.