Gene: ERBB4

Alternate names for this Gene: ALS19|HER4|p180erbB4

Gene Summary: This gene is a member of the Tyr protein kinase family and the epidermal growth factor receptor subfamily. It encodes a single-pass type I membrane protein with multiple cysteine rich domains, a transmembrane domain, a tyrosine kinase domain, a phosphotidylinositol-3 kinase binding site and a PDZ domain binding motif. The protein binds to and is activated by neuregulins and other factors and induces a variety of cellular responses including mitogenesis and differentiation. Multiple proteolytic events allow for the release of a cytoplasmic fragment and an extracellular fragment. Mutations in this gene have been associated with cancer. Alternatively spliced variants which encode different protein isoforms have been described; however, not all variants have been fully characterized.

Gene is located in Chromosome: 2

Location in Chromosome : 2q34

Description of this Gene: erb-b2 receptor tyrosine kinase 4

Type of Gene: protein-coding

Gene: MTND2P23

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