Gene: ESR2

Alternate names for this Gene: ER-BETA|ESR-BETA|ESRB|ESTRB|Erb|NR3A2|ODG8

Gene Summary: This gene encodes a member of the family of estrogen receptors and superfamily of nuclear receptor transcription factors. The gene product contains an N-terminal DNA binding domain and C-terminal ligand binding domain and is localized to the nucleus, cytoplasm, and mitochondria. Upon binding to 17beta-estradiol or related ligands, the encoded protein forms homo- or hetero-dimers that interact with specific DNA sequences to activate transcription. Some isoforms dominantly inhibit the activity of other estrogen receptor family members. Several alternatively spliced transcript variants of this gene have been described, but the full-length nature of some of these variants has not been fully characterized.

Gene is located in Chromosome: 14

Location in Chromosome : 14q23.2-q23.3

Description of this Gene: estrogen receptor 2

Type of Gene: protein-coding

Gene: SYNE2

Alternate names for this Gene: EDMD5|KASH2|NUA|NUANCE|Nesp2|Nesprin-2|SYNE-2|TROPH

Gene Summary: The protein encoded by this gene is a nuclear outer membrane protein that binds cytoplasmic F-actin. This binding tethers the nucleus to the cytoskeleton and aids in the maintenance of the structural integrity of the nucleus. Several transcript variants encoding different isoforms have been found for this gene.

Gene is located in Chromosome: 14

Location in Chromosome : 14q23.2

Description of this Gene: spectrin repeat containing nuclear envelope protein 2

Type of Gene: protein-coding