Gene: EXOC5

Alternate names for this Gene: HSEC10|PRO1912|SEC10|SEC10L1|SEC10P

Gene Summary: The protein encoded by this gene is a component of the exocyst complex, a multiple protein complex essential for targeting exocytic vesicles to specific docking sites on the plasma membrane. Though best characterized in yeast, the component proteins and functions of exocyst complex have been demonstrated to be highly conserved in higher eukaryotes. At least eight components of the exocyst complex, including this protein, are found to interact with the actin cytoskeletal remodeling and vesicle transport machinery. The complex is also essential for the biogenesis of epithelial cell surface polarity.

Gene is located in Chromosome: 14

Location in Chromosome : 14q22.3

Description of this Gene: exocyst complex component 5

Type of Gene: protein-coding

rs75165563 in EXOC5 gene and Exudative age-related macular degeneration PMID 30054556 2018 Genome-wide association study suggests four variants influencing outcomes with ranibizumab therapy in exudative age-related macular degeneration.

rs75165563 in EXOC5 gene and exudative macular degeneration PMID 30054556 2018 Genome-wide association study suggests four variants influencing outcomes with ranibizumab therapy in exudative age-related macular degeneration.