Gene: F2R

Alternate names for this Gene: CF2R|HTR|PAR-1|PAR1|TR

Gene Summary: Coagulation factor II receptor is a 7-transmembrane receptor involved in the regulation of thrombotic response. Proteolytic cleavage leads to the activation of the receptor. F2R is a G-protein coupled receptor family member. Alternative splicing results in multiple transcript variants.

Gene is located in Chromosome: 5

Location in Chromosome : 5q13.3

Description of this Gene: coagulation factor II thrombin receptor

Type of Gene: protein-coding

rs2227831 in F2R gene and Finding of Mean Corpuscular Hemoglobin PMID 30595370 2019 Leveraging Polygenic Functional Enrichment to Improve GWAS Power.

rs2227777 in F2R gene and Low density lipoprotein cholesterol measurement PMID 23063622 2012 Large-scale gene-centric meta-analysis across 32 studies identifies multiple lipid loci.

rs2227827 in F2R gene and Platelet Component Distribution Width Measurement PMID 27863252 2016 The Allelic Landscape of Human Blood Cell Trait Variation and Links to Common Complex Disease.

rs2227831 in F2R gene and Platelet mean volume determination (procedure) PMID 22139419 2011 New gene functions in megakaryopoiesis and platelet formation.

rs2227777 in F2R gene and Serum LDL cholesterol measurement PMID 23063622 2012 Large-scale gene-centric meta-analysis across 32 studies identifies multiple lipid loci.