Gene: FANCG

Alternate names for this Gene: FAG|XRCC9

Gene Summary: The Fanconi anemia complementation group (FANC) currently includes FANCA, FANCB, FANCC, FANCD1 (also called BRCA2), FANCD2, FANCE, FANCF, FANCG, FANCI, FANCJ (also called BRIP1), FANCL, FANCM and FANCN (also called PALB2). The previously defined group FANCH is the same as FANCA. Fanconi anemia is a genetically heterogeneous recessive disorder characterized by cytogenetic instability, hypersensitivity to DNA crosslinking agents, increased chromosomal breakage, and defective DNA repair. The members of the Fanconi anemia complementation group do not share sequence similarity; they are related by their assembly into a common nuclear protein complex. This gene encodes the protein for complementation group G.

Gene is located in Chromosome: 9

Location in Chromosome : 9p13.3

Description of this Gene: FA complementation group G

Type of Gene: protein-coding

rs1060501862 in FANCG gene and Fanconi Anemia PMID 12552564 2003 Spectrum of sequence variation in the FANCG gene: an International Fanconi Anemia Registry (IFAR) study.

PMID 9806458 1998 DNA extraction and stability for epidemiological studies.

PMID 11093276 2000 Spectrum of mutations in the Fanconi anaemia group G gene, FANCG/XRCC9.

PMID 25703136 2015 A common ancestral haplotype is strongly suggested in the Korean and Japanese patients with Fanconi anemia (FA), because common mutations have been frequently found: c.2546delC and c.3720_3724delAAACA of FANCA; c.307+1G>C, c.1066C>T, and c.1589_1591delATA of FANCG.

PMID 12673805 2003 Two common founder mutations of the fanconi anemia group G gene FANCG/XRCC9 in the Japanese population.

PMID 9806548 1998 The Fanconi anaemia group G gene FANCG is identical with XRCC9.

PMID 22778927 2012 Diagnosis of Fanconi Anemia: Mutation Analysis by Multiplex Ligation-Dependent Probe Amplification and PCR-Based Sanger Sequencing.

PMID 28717661 2017 A strategy for molecular diagnostics of Fanconi anemia in Brazilian patients.

rs121434425 in FANCG gene and fanconi anemia complementation group g PMID 11093276 2000 Spectrum of mutations in the Fanconi anaemia group G gene, FANCG/XRCC9.

PMID 9806548 1998 The Fanconi anaemia group G gene FANCG is identical with XRCC9.

PMID 15657175 2005 A common Fanconi anemia mutation in black populations of sub-Saharan Africa.

PMID 24763404 2014 Targeted resequencing of 52 bone marrow failure genes in patients with aplastic anemia reveals an increased frequency of novel variants of unknown significance only in SLX4.

PMID 23613520 2013 Massively parallel sequencing, aCGH, and RNA-Seq technologies provide a comprehensive molecular diagnosis of Fanconi anemia.

PMID 12552564 2003 Spectrum of sequence variation in the FANCG gene: an International Fanconi Anemia Registry (IFAR) study.