Gene: FBXL8

Alternate names for this Gene: FBL8

Gene Summary: This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of the ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbls class. It shares 78% sequence identity with the mouse protein.

Gene is located in Chromosome: 16

Location in Chromosome : 16q22.1

Description of this Gene: F-box and leucine rich repeat protein 8

Type of Gene: protein-coding

Gene: HSF4

Alternate names for this Gene: CTM|CTRCT5

Gene Summary: Heat-shock transcription factors (HSFs) activate heat-shock response genes under conditions of heat or other stresses. HSF4 lacks the carboxyl-terminal hydrophobic repeat which is shared among all vertebrate HSFs and has been suggested to be involved in the negative regulation of DNA binding activity. Two alternatively spliced transcripts encoding distinct isoforms and possessing different transcriptional activity have been described.

Gene is located in Chromosome: 16

Location in Chromosome : 16q22.1

Description of this Gene: heat shock transcription factor 4

Type of Gene: protein-coding