Gene: FCER1A

Alternate names for this Gene: FCE1A|FcERI

Gene Summary: The immunoglobulin epsilon receptor (IgE receptor) is the initiator of the allergic response. When two or more high-affinity IgE receptors are brought together by allergen-bound IgE molecules, mediators such as histamine that are responsible for allergy symptoms are released. This receptor is comprised of an alpha subunit, a beta subunit, and two gamma subunits. The protein encoded by this gene represents the alpha subunit.

Gene is located in Chromosome: 1

Location in Chromosome : 1q23.2

Description of this Gene: Fc fragment of IgE receptor Ia

Type of Gene: protein-coding

rs16841987 in FCER1A gene and C-reactive protein measurement PMID 22291609 2012 A genome-wide association scan on the levels of markers of inflammation in Sardinians reveals associations that underpin its complex regulation.

PMID 17903293 2007 Genome-wide association with select biomarker traits in the Framingham Heart Study.

rs7549785 in FCER1A gene and Hepatitis B, Chronic PMID 30972912 2019 FCER1A (rs7549785) and possibly POLR3G (rs7712322) are shown to be associated with peginterferon alfa-2a response in adult patients with chronic hepatitis B.

rs2427837 in FCER1A gene and Polysomnography PMID 23251661 2012 Novel genetic loci identified for the pathophysiology of childhood obesity in the Hispanic population.

rs2247584 in FCER1A gene and White Blood Cell Count procedure PMID 21738479 2011 Genome-wide association study of white blood cell count in 16,388 African Americans: the continental origins and genetic epidemiology network (COGENT).