Gene: FCRL1

Alternate names for this Gene: CD307a|FCRH1|IFGP1|IRTA5

Gene Summary: This gene encodes a member of the immunoglobulin receptor superfamily and is one of several Fc receptor-like glycoproteins clustered on the long arm of chromosome 1. The encoded protein contains three extracellular C2-like immunoglobulin domains, a transmembrane domain and a cytoplasmic domain with two immunoreceptor-tyrosine activation motifs. This protein may play a role in the regulation of cancer cell growth. Alternative splicing results in multiple transcript variants.

Gene is located in Chromosome: 1

Location in Chromosome : 1q23.1

Description of this Gene: Fc receptor like 1

Type of Gene: protein-coding

rs4971155 in FCRL1 gene and Blood Protein Measurement PMID 29875488 2018 Genomic atlas of the human plasma proteome.

rs2050568 in FCRL1 gene and Graves Disease PMID 21841780 2011 A genome-wide association study identifies two new risk loci for Graves' disease.

rs2050568 in FCRL1 gene and Multiple Sclerosis PMID 24076602 2013 Analysis of immune-related loci identifies 48 new susceptibility variants for multiple sclerosis.