Gene: FCSK

Alternate names for this Gene: 1110046B12Rik|CDGF2|FUK

Gene Summary: The protein encoded by this gene belongs to the GHMP (galacto-, homoserine, mevalonate and phosphomevalonate) kinase family and catalyzes the phosphorylation of L-fucose to form beta-L-fucose 1-phosphate. This enzyme catalyzes the first step in the utilization of free L-fucose in glycoprotein and glycolipid synthesis. L-fucose may be important in mediating a number of cell-cell interactions such as blood group antigen recognition, inflammation, and metastatis. While several transcript variants may exist for this gene, the full-length nature of only one has been described to date.

Gene is located in Chromosome: 16

Location in Chromosome : 16q22.1

Description of this Gene: fucose kinase

Type of Gene: protein-coding

rs62049035 in FCSK gene and Diastolic blood pressure PMID 30578418 2019 Trans-ethnic association study of blood pressure determinants in over 750,000 individuals.