Gene: FGD2

Alternate names for this Gene: ZFYVE4

Gene Summary: The protein encoded by this gene belongs to a family of guanine nucleotide exchange factors (GEFs) which control cytoskeleton-dependent membrane rearrangements by activating the cell division cycle 42 (CDC42) protein. This gene is expressed in B lymphocytes, macrophages, and dendritic cells. The encoded protein may play a role in leukocyte signaling and vesicle trafficking in antigen-presenting cells in the immune system.

Gene is located in Chromosome: 6

Location in Chromosome : 6p21.2

Description of this Gene: FYVE, RhoGEF and PH domain containing 2

Type of Gene: protein-coding

rs831497 in FGD2 gene and Eczema PMID 30595370 2019 Leveraging Polygenic Functional Enrichment to Improve GWAS Power.

rs1724088 in FGD2 gene and Hypothyroidism PMID 30595370 2019 Leveraging Polygenic Functional Enrichment to Improve GWAS Power.