Gene: FGG
Alternate names for this Gene: -
Gene Summary: The protein encoded by this gene is the gamma component of fibrinogen, a blood-borne glycoprotein comprised of three pairs of nonidentical polypeptide chains. Following vascular injury, fibrinogen is cleaved by thrombin to form fibrin which is the most abundant component of blood clots. In addition, various cleavage products of fibrinogen and fibrin regulate cell adhesion and spreading, display vasoconstrictor and chemotactic activities, and are mitogens for several cell types. Mutations in this gene lead to several disorders, including dysfibrinogenemia, hypofibrinogenemia and thrombophilia. Alternative splicing results in transcript variants encoding different isoforms.
Gene is located in Chromosome: 4
Location in Chromosome : 4q32.1
Description of this Gene: fibrinogen gamma chain
Type of Gene: protein-coding
rs148685782 in
FGG gene and
Bleeding tendency
PMID 31064749 2019 Diagnostic high-throughput sequencing of 2396 patients with bleeding, thrombotic, and platelet disorders.
rs75848804 in
FGG gene and
Congenital hypofibrinogenemia
PMID 25427968 2015 Clinical and molecular characterisation of 21 patients affected by quantitative fibrinogen deficiency.
rs121913088 in
FGG gene and
Dysfibrinogenemia, Congenital
PMID 2257302 1990 Fibrinogen Baltimore I: polymerization defect associated with a gamma 292Gly----Val (GGC----GTC) mutation.
PMID 2976995 1988 "Normal plasmic cleavage of the gamma-chain variant of ""fibrinogen Saga"" with an Arg-275 to His substitution."
PMID 3708159 1986 Characterization of fibrinogen Milano I: amino acid exchange gamma 330 Asp----Val impairs fibrin polymerization.
PMID 15632207 2005 Fibrinogen Philadelphia, a hypodysfibrinogenemia characterized by abnormal polymerization and fibrinogen hypercatabolism due to gamma S378P mutation.
rs148685782 in
FGG gene and
Fibrinogen assay
PMID 26561523 2016 A meta-analysis of 120 246 individuals identifies 18 new loci for fibrinogen concentration.
PMID 20978265 2011 The association of FGG rs2066861 with fibrinogen differed according to assay type used to measure fibrinogen.
rs2066861 in
FGG gene and
Fibrinogen, CTCAE
PMID 20978265 2011 The association of FGG rs2066861 with fibrinogen differed according to assay type used to measure fibrinogen.
rs148685782 in
FGG gene and
Glycine measurement
PMID 30837465 2019 Assessing the causal association of glycine with risk of cardio-metabolic diseases.
rs121913087 in
FGG gene and
Hypofibrinogenemia
PMID 31064749 2019 Diagnostic high-throughput sequencing of 2396 patients with bleeding, thrombotic, and platelet disorders.
rs2066861 in
FGG gene and
Venous Thromboembolism
PMID 21980494 2011 Genetics of venous thrombosis: insights from a new genome wide association study.
PMID 31420334 2019 Genomic and transcriptomic association studies identify 16 novel susceptibility loci for venous thromboembolism.
PMID 31676865 2019 Genome-wide association analysis of venous thromboembolism identifies new risk loci and genetic overlap with arterial vascular disease.
PMID 25772935 2015 Meta-analysis of 65,734 individuals identifies TSPAN15 and SLC44A2 as two susceptibility loci for venous thromboembolism.
PMID 28373160 2017 Genetic Analysis of Venous Thromboembolism in UK Biobank Identifies the ZFPM2 Locus and Implicates Obesity as a Causal Risk Factor.
rs2066854 in
FGG gene and
Venous Thrombosis
PMID 22675575 2012 Caution in interpreting results from imputation analysis when linkage disequilibrium extends over a large distance: a case study on venous thrombosis.
rs2066861 in
FGG gene and
fibrinogen activity
PMID 20978265 2011 The association of FGG rs2066861 with fibrinogen differed according to assay type used to measure fibrinogen.