Gene: FLG-AS1
Alternate names for this Gene: -
Gene Summary:
Gene is located in Chromosome: 1
Location in Chromosome : 1q21.3
Description of this Gene: FLG antisense RNA 1
Type of Gene: ncRNA
Gene: FLG
Alternate names for this Gene: ATOD2
Gene Summary: The protein encoded by this gene is an intermediate filament-associated protein that aggregates keratin intermediate filaments in mammalian epidermis. It is initially synthesized as a polyprotein precursor, profilaggrin (consisting of multiple filaggrin units of 324 aa each), which is localized in keratohyalin granules, and is subsequently proteolytically processed into individual functional filaggrin molecules. Mutations in this gene are associated with ichthyosis vulgaris.
Gene is located in Chromosome: 1
Location in Chromosome : 1q21.3
Description of this Gene: filaggrin
Type of Gene: protein-coding
rs535289422 in
FLG-AS1;FLG gene and
Ichthyosis Vulgaris
PMID 21923666 2011 Filaggrin gene mutations are associated with independent atopic asthma in Chinese patients.
PMID 22220561 2013 Mutations analysis in filaggrin gene in northern China patients with atopic dermatitis.
PMID 21428977 2011 Wide spectrum of filaggrin-null mutations in atopic dermatitis highlights differences between Singaporean Chinese and European populations.
PMID 18200065 2008 Specific filaggrin mutations cause ichthyosis vulgaris and are significantly associated with atopic dermatitis in Japan.