Gene: FN1

Alternate names for this Gene: CIG|ED-B|FINC|FN|FNZ|GFND|GFND2|LETS|MSF|SMDCF

Gene Summary: This gene encodes fibronectin, a glycoprotein present in a soluble dimeric form in plasma, and in a dimeric or multimeric form at the cell surface and in extracellular matrix. The encoded preproprotein is proteolytically processed to generate the mature protein. Fibronectin is involved in cell adhesion and migration processes including embryogenesis, wound healing, blood coagulation, host defense, and metastasis. The gene has three regions subject to alternative splicing, with the potential to produce 20 different transcript variants, at least one of which encodes an isoform that undergoes proteolytic processing. The full-length nature of some variants has not been determined.

Gene is located in Chromosome: 2

Location in Chromosome : 2q35

Description of this Gene: fibronectin 1

Type of Gene: protein-coding

rs17517928 in FN1 gene and Coronary Artery Disease PMID 28714974 2017 Genetic analysis in UK Biobank links insulin resistance and transendothelial migration pathways to coronary artery disease.

rs137854488 in FN1 gene and GLOMERULOPATHY WITH FIBRONECTIN DEPOSITS 2 (disorder) PMID 18268355 2008 Mutations in FN1 cause glomerulopathy with fibronectin deposits.

rs1250248 in FN1 gene and Serum total cholesterol measurement PMID 28334899 2017 Association analyses of East Asian individuals and trans-ancestry analyses with European individuals reveal new loci associated with cholesterol and triglyceride levels.

rs1181638652 in FN1 gene and Spondylometaphyseal dysplasia, 'corner fracture' type PMID 29100092 2017 "Mutations in Fibronectin Cause a Subtype of Spondylometaphyseal Dysplasia with ""Corner Fractures""."

rs6728999 in FN1 gene and Triglycerides measurement PMID 23063622 2012 Large-scale gene-centric meta-analysis across 32 studies identifies multiple lipid loci.

rs1250248 in FN1 gene and Vital capacity PMID 30595370 2019 Leveraging Polygenic Functional Enrichment to Improve GWAS Power.