Gene: FUBP1

Alternate names for this Gene: FBP|FUBP|hDH V

Gene Summary: The protein encoded by this gene is a single stranded DNA-binding protein that binds to multiple DNA elements, including the far upstream element (FUSE) located upstream of c-myc. Binding to FUSE occurs on the non-coding strand, and is important to the regulation of c-myc in undifferentiated cells. This protein contains three domains, an amphipathic helix N-terminal domain, a DNA-binding central domain, and a C-terminal transactivation domain that contains three tyrosine-rich motifs. The N-terminal domain is thought to repress the activity of the C-terminal domain. This protein is also thought to bind RNA, and contains 3'-5' helicase activity with in vitro activity on both DNA-DNA and RNA-RNA duplexes. Aberrant expression of this gene has been found in malignant tissues, and this gene is important to neural system and lung development. Binding of this protein to viral RNA is thought to play a role in several viral diseases, including hepatitis C and hand, foot and mouth disease. Alternative splicing results in multiple transcript variants.

Gene is located in Chromosome: 1

Location in Chromosome : 1p31.1

Description of this Gene: far upstream element binding protein 1

Type of Gene: protein-coding

Gene: GIPC2

Alternate names for this Gene: SEMCAP-2|SEMCAP2

Gene Summary:

Gene is located in Chromosome: 1

Location in Chromosome : 1p31.1

Description of this Gene: GIPC PDZ domain containing family member 2

Type of Gene: protein-coding

Gene: DNAJB4

Alternate names for this Gene: DNAJW|DjB4|HLJ1

Gene Summary: The protein encoded by this gene is a molecular chaperone, tumor suppressor, and member of the heat shock protein-40 family. The encoded protein binds the cell adhesion protein E-cadherin and targets it to the plasma membrane. This protein also binds incorrectly folded E-cadherin and targets it for endoplasmic reticulum-associated degradation. This gene is a strong tumor suppressor for colorectal carcinoma, and downregulation of it may serve as a good biomarker for predicting patient outcomes. Several transcript variants encoding different isoforms have been found for this gene.

Gene is located in Chromosome: 1

Location in Chromosome : 1p31.1

Description of this Gene: DnaJ heat shock protein family (Hsp40) member B4

Type of Gene: protein-coding

rs12401738 in FUBP1;GIPC2;DNAJB4 gene and Body mass index PMID 25673413 2015 Genetic studies of body mass index yield new insights for obesity biology.

PMID 26426971 2015 The Influence of Age and Sex on Genetic Associations with Adult Body Size and Shape: A Large-Scale Genome-Wide Interaction Study.

PMID 28443625 2017 Genome-wide meta-analysis of 241,258 adults accounting for smoking behaviour identifies novel loci for obesity traits.

rs12401738 in FUBP1;GIPC2;DNAJB4 gene and Smoking PMID 28443625 2017 Genome-wide meta-analysis of 241,258 adults accounting for smoking behaviour identifies novel loci for obesity traits.