Gene: FZD6
Alternate names for this Gene: FZ-6|FZ6|HFZ6|NDNC1|NDNC10
Gene Summary: This gene represents a member of the 'frizzled' gene family, which encode 7-transmembrane domain proteins that are receptors for Wnt signaling proteins. The protein encoded by this family member contains a signal peptide, a cysteine-rich domain in the N-terminal extracellular region, and seven transmembrane domains, but unlike other family members, this protein does not contain a C-terminal PDZ domain-binding motif. This protein functions as a negative regulator of the canonical Wnt/beta-catenin signaling cascade, thereby inhibiting the processes that trigger oncogenic transformation, cell proliferation, and inhibition of apoptosis. Alternative splicing results in multiple transcript variants, some of which do not encode a protein with a predicted signal peptide.
Gene is located in Chromosome: 8
Location in Chromosome : 8q22.3
Description of this Gene: frizzled class receptor 6
Type of Gene: protein-coding