Gene: GADD45A

Alternate names for this Gene: DDIT1|GADD45

Gene Summary: This gene is a member of a group of genes whose transcript levels are increased following stressful growth arrest conditions and treatment with DNA-damaging agents. The protein encoded by this gene responds to environmental stresses by mediating activation of the p38/JNK pathway via MTK1/MEKK4 kinase. The DNA damage-induced transcription of this gene is mediated by both p53-dependent and -independent mechanisms. Alternatively spliced transcript variants encoding distinct isoforms have been found for this gene.

Gene is located in Chromosome: 1

Location in Chromosome : 1p31.3

Description of this Gene: growth arrest and DNA damage inducible alpha

Type of Gene: protein-coding