Gene: GALNT14

Alternate names for this Gene: GALNT15|GalNac-T10|GalNac-T14

Gene Summary: This gene encodes a Golgi protein which is a member of the polypeptide N-acetylgalactosaminyltransferase (ppGalNAc-Ts) protein family. These enzymes catalyze the transfer of N-acetyl-D-galactosamine (GalNAc) to the hydroxyl groups on serines and threonines in target peptides. The encoded protein has been shown to transfer GalNAc to large proteins like mucins. Alterations in this gene may play a role in cancer progression and response to chemotherapy.

Gene is located in Chromosome: 2

Location in Chromosome : 2p23.1

Description of this Gene: polypeptide N-acetylgalactosaminyltransferase 14

Type of Gene: protein-coding

rs10205350 in GALNT14 gene and Autistic Disorder PMID 22843504 2012 Individual common variants exert weak effects on the risk for autism spectrum disorders.

rs17393065 in GALNT14 gene and Eye Movement Measurements PMID 30120336 2018 Genome-wide Association Analysis of Eye Movement Dysfunction in Schizophrenia.

rs201118996 in GALNT14 gene and Hydrops Fetalis, Non-Immune PMID 26036949 2015 Identification of embryonic lethal genes in humans by autozygosity mapping and exome sequencing in consanguineous families.

rs6543603 in GALNT14 gene and Leukemia, Myelocytic, Acute PMID 27903959 2017 Genome-wide haplotype association study identify the FGFR2 gene as a risk gene for acute myeloid leukemia.

rs11687856 in GALNT14 gene and Narcolepsy PMID 19629137 2009 Genome-wide association database developed in the Japanese Integrated Database Project.