Gene: GDF7

Alternate names for this Gene: BMP12

Gene Summary: This gene encodes a secreted ligand of the TGF-beta (transforming growth factor-beta) superfamily of proteins. Ligands of this family bind various TGF-beta receptors leading to recruitment and activation of SMAD family transcription factors that regulate gene expression. The encoded preproprotein is proteolytically processed to generate each subunit of the disulfide-linked homodimer. This protein may play a role in the differentiation of tendon cells and spinal cord interneurons. A mutation in this gene may be associated with increased risk for Barrett's esophagus and esophageal adenocarcinoma.

Gene is located in Chromosome: 2

Location in Chromosome : 2p24.1

Description of this Gene: growth differentiation factor 7

Type of Gene: protein-coding

rs7255 in GDF7 gene and Adenocarcinoma Of Esophagus PMID 27527254 2016 Genome-wide association studies in oesophageal adenocarcinoma and Barrett's oesophagus: a large-scale meta-analysis.

rs7255 in GDF7 gene and Barrett Esophagus PMID 27527254 2016 Genome-wide association studies in oesophageal adenocarcinoma and Barrett's oesophagus: a large-scale meta-analysis.

rs9306895 in GDF7 gene and Prostate carcinoma PMID 29892016 2018 Association analyses of more than 140,000 men identify 63 new prostate cancer susceptibility loci.

rs7255 in GDF7 gene and Systolic Pressure PMID 30578418 2019 Trans-ethnic association study of blood pressure determinants in over 750,000 individuals.