Gene: GEN1

Alternate names for this Gene: Gen

Gene Summary: This gene encodes a member of the Rad2/xeroderma pigmentosum group G nuclease family, whose members are characterized by N-terminal and internal xeroderma pigmentosum group G nuclease domains followed by helix-hairpin-helix domains and disordered C-terminal domains. The protein encoded by this gene is involved in resolution of Holliday junctions, which are intermediate four-way structures that covalently link DNA during homologous recombination and double-strand break repair. The protein resolves Holliday junctions by creating dual incisions across the junction to produce nicked duplex products that can be ligated. In addition, this protein has been found to localize to centrosomes where it has been implicated in regulation of centrosome integrity. Alternative splicing results in multiple transcript variants.

Gene is located in Chromosome: 2

Location in Chromosome : 2p24.2

Description of this Gene: GEN1 Holliday junction 5' flap endonuclease

Type of Gene: protein-coding

Gene: SMC6

Alternate names for this Gene: SMC-6|SMC6L1|hSMC6

Gene Summary:

Gene is located in Chromosome: 2

Location in Chromosome : 2p24.2

Description of this Gene: structural maintenance of chromosomes 6

Type of Gene: protein-coding

Gene: LOC105373449

Alternate names for this Gene:

Gene Summary:

Gene is located in Chromosome:

Location in Chromosome :

Description of this Gene:

Type of Gene:

rs2615048 in GEN1;SMC6;LOC105373449 gene and Lymphocyte Count measurement PMID 22286170 2012 The combination of a genome-wide association study of lymphocyte count and analysis of gene expression data reveals novel asthma candidate genes.