Gene: GIPC2

Alternate names for this Gene: SEMCAP-2|SEMCAP2

Gene Summary:

Gene is located in Chromosome: 1

Location in Chromosome : 1p31.1

Description of this Gene: GIPC PDZ domain containing family member 2

Type of Gene: protein-coding

Gene: DNAJB4

Alternate names for this Gene: DNAJW|DjB4|HLJ1

Gene Summary: The protein encoded by this gene is a molecular chaperone, tumor suppressor, and member of the heat shock protein-40 family. The encoded protein binds the cell adhesion protein E-cadherin and targets it to the plasma membrane. This protein also binds incorrectly folded E-cadherin and targets it for endoplasmic reticulum-associated degradation. This gene is a strong tumor suppressor for colorectal carcinoma, and downregulation of it may serve as a good biomarker for predicting patient outcomes. Several transcript variants encoding different isoforms have been found for this gene.

Gene is located in Chromosome: 1

Location in Chromosome : 1p31.1

Description of this Gene: DnaJ heat shock protein family (Hsp40) member B4

Type of Gene: protein-coding

rs4130548 in GIPC2;DNAJB4 gene and Body mass index PMID 28448500 2017 Genome-wide physical activity interactions in adiposity - A meta-analysis of 200,452 adults.

PMID 30108127 2018 A Large Multiethnic Genome-Wide Association Study of Adult Body Mass Index Identifies Novel Loci.

rs4130548 in GIPC2;DNAJB4 gene and Intelligence PMID 31374203 2019 Pleiotropic Meta-Analysis of Cognition, Education, and Schizophrenia Differentiates Roles of Early Neurodevelopmental and Adult Synaptic Pathways.

rs4130548 in GIPC2;DNAJB4 gene and Physical Activity Measurement PMID 28448500 2017 Genome-wide physical activity interactions in adiposity - A meta-analysis of 200,452 adults.

rs4130548 in GIPC2;DNAJB4 gene and Schizophrenia PMID 31374203 2019 Pleiotropic Meta-Analysis of Cognition, Education, and Schizophrenia Differentiates Roles of Early Neurodevelopmental and Adult Synaptic Pathways.

rs4130548 in GIPC2;DNAJB4 gene and Waist Circumference PMID 25673412 2015 New genetic loci link adipose and insulin biology to body fat distribution.