Gene: GLE1

Alternate names for this Gene: CAAHC|CAAHD|GLE1L|LCCS|LCCS1|hGLE1

Gene Summary: This gene encodes a predicted 75-kDa polypeptide with high sequence and structure homology to yeast Gle1p, which is nuclear protein with a leucine-rich nuclear export sequence essential for poly(A)+RNA export. Inhibition of human GLE1L by microinjection of antibodies against GLE1L in HeLa cells resulted in inhibition of poly(A)+RNA export. Immunoflourescence studies show that GLE1L is localized at the nuclear pore complexes. This localization suggests that GLE1L may act at a terminal step in the export of mature RNA messages to the cytoplasm. Two alternatively spliced transcript variants encoding different isoforms have been found for this gene.

Gene is located in Chromosome: 9

Location in Chromosome : 9q34.11

Description of this Gene: GLE1 RNA export mediator

Type of Gene: protein-coding

Gene: LOC101929270

Alternate names for this Gene:

Gene Summary:

Gene is located in Chromosome:

Location in Chromosome :

Description of this Gene:

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rs121434408 in GLE1;LOC101929270 gene and Lethal Arthrogryposis With Anterior Horn Cell Disease PMID 18204449 2008 Mutations in mRNA export mediator GLE1 result in a fetal motoneuron disease.