Gene: GPLD1

Alternate names for this Gene: GPIPLD|GPIPLDM|PIGPLD|PIGPLD1|PLD

Gene Summary: Many proteins are tethered to the extracellular face of eukaryotic plasma membranes by a glycosylphosphatidylinositol (GPI) anchor. The GPI-anchor is a glycolipid found on many blood cells. The protein encoded by this gene is a GPI degrading enzyme. Glycosylphosphatidylinositol specific phospholipase D1 hydrolyzes the inositol phosphate linkage in proteins anchored by phosphatidylinositol glycans, thereby releasing the attached protein from the plasma membrane.

Gene is located in Chromosome: 6

Location in Chromosome : 6p22.3

Description of this Gene: glycosylphosphatidylinositol specific phospholipase D1

Type of Gene: protein-coding

rs138612106 in GPLD1 gene and Alkaline phosphatase measurement PMID 29403010 2018 Genetic analysis of quantitative traits in the Japanese population links cell types to complex human diseases.

PMID 22001757 2011 Genome-wide association study identifies loci influencing concentrations of liver enzymes in plasma.

PMID 31675503 2019 Uganda Genome Resource Enables Insights into Population History and Genomic Discovery in Africa.

PMID 20139978 2010 Genome-wide association study of hematological and biochemical traits in a Japanese population.

PMID 18940312 2008 Population-based genome-wide association studies reveal six loci influencing plasma levels of liver enzymes.

rs6918194 in GPLD1 gene and Finding of Mean Corpuscular Hemoglobin PMID 30595370 2019 Leveraging Polygenic Functional Enrichment to Improve GWAS Power.

rs9467160 in GPLD1 gene and Finding of liver enzyme levels PMID 18940312 2008 Population-based genome-wide association studies reveal six loci influencing plasma levels of liver enzymes.

rs9467160 in GPLD1 gene and Measurement of liver enzyme PMID 18940312 2008 Population-based genome-wide association studies reveal six loci influencing plasma levels of liver enzymes.

rs1126617 in GPLD1 gene and Serum gamma-glutamyl transferase measurement PMID 22001757 2011 Genome-wide association study identifies loci influencing concentrations of liver enzymes in plasma.

rs6911965 in GPLD1 gene and Uric acid measurement (procedure) PMID 20139978 2010 Genome-wide association study of hematological and biochemical traits in a Japanese population.