Gene: GPR153

Alternate names for this Gene: PGR1

Gene Summary: This gene encodes an integral membrane protein that belongs to the Class A rhodopsin superfamily of G protein coupled receptors. The encoded protein is expressed primarily in the central nervous system. A knockdown of the orthologous gene in rat is associated with a significant reduction in food intake and impaired decision making ability. Mutations in this gene are associated with schizophrenia, autism, and other neuropsychiatric disorders. The expression of this gene is activated by the glioma-associated oncogene homolog 1 transcription factor which, in turn, is activated by sonic hedgehog in normal and tumorigenic cells.

Gene is located in Chromosome: 1

Location in Chromosome : 1p36.31

Description of this Gene: G protein-coupled receptor 153

Type of Gene: protein-coding