Gene: GPX2

Alternate names for this Gene: GI-GPx|GPRP|GPRP-2|GPx-2|GPx-GI|GSHPX-GI|GSHPx-2

Gene Summary: The protein encoded by this gene belongs to the glutathione peroxidase family, members of which catalyze the reduction of organic hydroperoxides and hydrogen peroxide (H2O2) by glutathione, and thereby protect cells against oxidative damage. Several isozymes of this gene family exist in vertebrates, which vary in cellular location and substrate specificity. This isozyme is predominantly expressed in the gastrointestinal tract (also in liver in human), is localized in the cytoplasm, and whose preferred substrate is hydrogen peroxide. Overexpression of this gene is associated with increased differentiation and proliferation in colorectal cancer. This isozyme is also a selenoprotein, containing the rare amino acid selenocysteine (Sec) at its active site. Sec is encoded by the UGA codon, which normally signals translation termination. The 3' UTRs of selenoprotein mRNAs contain a conserved stem-loop structure, designated the Sec insertion sequence (SECIS) element, that is necessary for the recognition of UGA as a Sec codon, rather than as a stop signal. Alternatively spliced transcript variants have been found for this gene.

Gene is located in Chromosome: 14

Location in Chromosome : 14q23.3

Description of this Gene: glutathione peroxidase 2

Type of Gene: protein-coding

Gene: CHURC1

Alternate names for this Gene: C14orf52|My015|chch

Gene Summary:

Gene is located in Chromosome: 14

Location in Chromosome : 14q23.3

Description of this Gene: churchill domain containing 1

Type of Gene: protein-coding

Gene: CHURC1-FNTB

Alternate names for this Gene: FNTB|FTase-beta

Gene Summary: This locus represents naturally occurring read-through transcription between the neighboring CHURC1 (churchill domain containing 1) and FNTB (farnesyltransferase, CAAX box, beta) on chromosome 14. The read-through transcript produces a fusion protein that shares sequence identity with each individual gene product.

Gene is located in Chromosome: 14

Location in Chromosome : 14q23.3

Description of this Gene: CHURC1-FNTB readthrough

Type of Gene: protein-coding

rs2412065 in GPX2;CHURC1;CHURC1-FNTB gene and Lymphocyte Count measurement PMID 22286170 2012 The combination of a genome-wide association study of lymphocyte count and analysis of gene expression data reveals novel asthma candidate genes.