Gene: GRAMD4

Alternate names for this Gene: DIP

Gene Summary: GRAMD4 is a mitochondrial effector of E2F1 (MIM 189971)-induced apoptosis (Stanelle et al., 2005 [PubMed 15565177]).[supplied by OMIM, Jan 2011]. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. ##Evidence-Data-START## Transcript exon combination :: AB018310.2 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1966682, SAMEA1968540 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000406902.6/ ENSP00000385689.1 RefSeq Select criteria :: based on conservation ##RefSeq-Attributes-END##

Gene is located in Chromosome: 22

Location in Chromosome : 22q13.31

Description of this Gene: GRAM domain containing 4

Type of Gene: protein-coding

rs138517 in GRAMD4 gene and Leukemia, Myelocytic, Acute PMID 27903959 2017 Genome-wide haplotype association study identify the FGFR2 gene as a risk gene for acute myeloid leukemia.