Gene: GRAP

Alternate names for this Gene: DFNB114

Gene Summary: This gene encodes a member of the GRB2/Sem5/Drk family and functions as a cytoplasmic signaling protein which contains an SH2 domain flanked by two SH3 domains. The SH2 domain interacts with ligand-activated receptors for stem cell factor and erythropoietin, and facilitates the formation of a stable complex with the BCR-ABL oncoprotein. This protein also associates with the Ras guanine nucleotide exchange factor SOS1 (son of sevenless homolog 1) through its N-terminal SH3 domain. In general, it couples signals from receptor and cytoplasmic tyrosine kinases to the Ras signaling pathway.

Gene is located in Chromosome: 17

Location in Chromosome : 17p11.2

Description of this Gene: GRB2 related adaptor protein

Type of Gene: protein-coding

Gene: SLC5A10

Alternate names for this Gene: SGLT-5|SGLT5

Gene Summary: This gene is a member of the sodium/glucose transporter family. Members of this family are sodium-dependent transporters and can be divided into two subfamilies based on sequence homology, one that co-transports sugars and the second that transports molecules such as ascorbate, choline, iodide, lipoate, monocaroboxylates, and pantothenate. The protein encoded by this gene has the highest affinity for mannose and has been reported to be most highly expressed in the kidney. This protein may function as a kidney-specific, sodium-dependent mannose and fructose co-transporter. Alternative splicing results in multiple transcript variants that encode different protein isoforms.

Gene is located in Chromosome: 17

Location in Chromosome : 17p11.2

Description of this Gene: solute carrier family 5 member 10

Type of Gene: protein-coding