Gene: GRK3

Alternate names for this Gene: ADRBK2|BARK2

Gene Summary: The beta-adrenergic receptor kinase specifically phosphorylates the agonist-occupied form of the beta-adrenergic and related G protein-coupled receptors. Overall, the beta adrenergic receptor kinase 2 has 85% amino acid similarity with beta adrenergic receptor kinase 1, with the protein kinase catalytic domain having 95% similarity. These data suggest the existence of a family of receptor kinases which may serve broadly to regulate receptor function.

Gene is located in Chromosome: 22

Location in Chromosome : 22q12.1

Description of this Gene: G protein-coupled receptor kinase 3

Type of Gene: protein-coding

rs12158587 in GRK3 gene and Triglycerides measurement PMID 23063622 2012 Large-scale gene-centric meta-analysis across 32 studies identifies multiple lipid loci.