Gene: GRM8

Alternate names for this Gene: GLUR8|GPRC1H|MGLUR8|mGlu8

Gene Summary: L-glutamate is the major excitatory neurotransmitter in the central nervous system and activates both ionotropic and metabotropic glutamate receptors. Glutamatergic neurotransmission is involved in most aspects of normal brain function and can be perturbed in many neuropathologic conditions. The metabotropic glutamate receptors are a family of G protein-coupled receptors, that have been divided into 3 groups on the basis of sequence homology, putative signal transduction mechanisms, and pharmacologic properties. Group I includes GRM1 and GRM5 and these receptors have been shown to activate phospholipase C. Group II includes GRM2 and GRM3 while Group III includes GRM4, GRM6, GRM7 and GRM8. Group II and III receptors are linked to the inhibition of the cyclic AMP cascade but differ in their agonist selectivities. Alternatively spliced transcript variants encoding different isoforms have been described for this gene.

Gene is located in Chromosome: 7

Location in Chromosome : 7q31.33

Description of this Gene: glutamate metabotropic receptor 8

Type of Gene: protein-coding

rs17691394 in GRM8 gene and ACQUIRED IMMUNODEFICIENCY SYNDROME, PROGRESSION TO PMID 20009918 2010 A genome-wide association study of carotid atherosclerosis in HIV-infected men.

rs17691394 in GRM8 gene and AIDS, PROGRESSION TO PMID 20009918 2010 A genome-wide association study of carotid atherosclerosis in HIV-infected men.

rs2283093 in GRM8 gene and Body mass index PMID 30595370 2019 Leveraging Polygenic Functional Enrichment to Improve GWAS Power.

rs12706746 in GRM8 gene and Gastroesophageal reflux disease PMID 31527586 2019 Gastroesophageal reflux GWAS identifies risk loci that also associate with subsequent severe esophageal diseases.

rs17691394 in GRM8 gene and HIV-1 infection PMID 20009918 2010 A genome-wide association study of carotid atherosclerosis in HIV-infected men.

rs17691394 in GRM8 gene and HIV-1, RESISTANCE TO PMID 20009918 2010 A genome-wide association study of carotid atherosclerosis in HIV-infected men.

rs17691394 in GRM8 gene and HUMAN IMMUNODEFICIENCY VIRUS TYPE 1, SUSCEPTIBILITY TO PMID 20009918 2010 A genome-wide association study of carotid atherosclerosis in HIV-infected men.

rs10487465 in GRM8 gene and Narcolepsy PMID 19629137 2009 Genome-wide association database developed in the Japanese Integrated Database Project.

rs10232276 in GRM8 gene and mathematical ability PMID 30038396 2018 Gene discovery and polygenic prediction from a genome-wide association study of educational attainment in 1.1 million individuals.