Gene: GUCY1B1

Alternate names for this Gene: GC-S-beta-1|GC-SB3|GUC1B3|GUCB3|GUCSB3|GUCY1B3

Gene Summary: This gene encodes the beta subunit of the soluble guanylate cyclase (sGC), which catalyzes the conversion of GTP (guanosine triphosphate) to cGMP (cyclic guanosine monophosphate). The encoded protein contains an HNOX domain, which serves as a receptor for ligands such as nitric oxide, oxygen and nitrovasodilator drugs. Alternative splicing results in multiple transcript variants.

Gene is located in Chromosome: 4

Location in Chromosome : 4q32.1

Description of this Gene: guanylate cyclase 1 soluble subunit beta 1

Type of Gene: protein-coding

rs2219538 in GUCY1B1 gene and Mean blood pressure PMID 30487518 2018 Interethnic analyses of blood pressure loci in populations of East Asian and European descent.

rs2219538 in GUCY1B1 gene and Systolic Pressure PMID 30487518 2018 Interethnic analyses of blood pressure loci in populations of East Asian and European descent.