Gene: H1-8

Alternate names for this Gene: H1.8|H1FOO|H1oo|osH1

Gene Summary: Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Nucleosomes consist of approximately 146 bp of DNA wrapped around a histone octamer composed of pairs of each of the four core histones (H2A, H2B, H3, and H4). The chromatin fiber is further compacted through the interaction of a linker histone, H1, with the DNA between the nucleosomes to form higher order chromatin structures. The protein encoded is a replication-independent histone that is a member of the histone H1 family. This gene contains introns, unlike most histone genes. The related mouse gene is expressed only in oocytes.

Gene is located in Chromosome: 3

Location in Chromosome : 3q22.1

Description of this Gene: H1.8 linker histone

Type of Gene: protein-coding

rs575341705 in H1-8 gene and Lean body mass PMID 28552196 2017 Whole-Genome Sequencing Coupled to Imputation Discovers Genetic Signals for Anthropometric Traits.