Gene: H2BC4

Alternate names for this Gene: H2B.1|H2B/l|H2BC10|H2BC6|H2BC7|H2BC8|H2BFL|HIST1H2BC|dJ221C16.3

Gene Summary: Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Two molecules of each of the four core histones (H2A, H2B, H3, and H4) form an octamer, around which approximately 146 bp of DNA is wrapped in repeating units, called nucleosomes. The linker histone, H1, interacts with linker DNA between nucleosomes and functions in the compaction of chromatin into higher order structures. The protein has antibacterial and antifungal antimicrobial activity. The main transcript variant of this gene is intronless and encodes a replication-dependent histone that is a member of the histone H2B family. This transcript variant lacks a polyA tail but instead contains a palindromic termination element. This gene is found in the large histone gene cluster on chromosome 6.

Gene is located in Chromosome: 6

Location in Chromosome : 6p22.2

Description of this Gene: H2B clustered histone 4

Type of Gene: protein-coding

Gene: H2AC6

Alternate names for this Gene: H2A/l|H2AFL|HIST1H2AC|dJ221C16.4

Gene Summary: Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Two molecules of each of the four core histones (H2A, H2B, H3, and H4) form an octamer, around which approximately 146 bp of DNA is wrapped in repeating units, called nucleosomes. The linker histone, H1, interacts with linker DNA between nucleosomes and functions in the compaction of chromatin into higher order structures. This gene is intronless and encodes a replication-dependent histone that is a member of the histone H2A family. Transcripts from this gene lack polyA tails but instead contain a palindromic termination element. This gene is found in the large histone gene cluster on chromosome 6.

Gene is located in Chromosome: 6

Location in Chromosome : 6p22.2

Description of this Gene: H2A clustered histone 6

Type of Gene: protein-coding

rs129128 in H2BC4;H2AC6 gene and Corpuscular Hemoglobin Concentration Mean PMID 23222517 2012 Seventy-five genetic loci influencing the human red blood cell.

rs129128 in H2BC4;H2AC6 gene and Finding of Mean Corpuscular Hemoglobin PMID 22560525 2012 Genetic Loci implicated in erythroid differentiation and cell cycle regulation are associated with red blood cell traits.

rs129128 in H2BC4;H2AC6 gene and Hemoglobin measurement PMID 19820698 2009 Genome-wide association study identifies variants in TMPRSS6 associated with hemoglobin levels.

rs129128 in H2BC4;H2AC6 gene and Hemoglobin, CTCAE PMID 19820698 2009 Genome-wide association study identifies variants in TMPRSS6 associated with hemoglobin levels.

rs129128 in H2BC4;H2AC6 gene and Mean Corpuscular Volume (result) PMID 22560525 2012 Genetic Loci implicated in erythroid differentiation and cell cycle regulation are associated with red blood cell traits.

rs129128 in H2BC4;H2AC6 gene and Mean corpuscular hemoglobin concentration determination PMID 22560525 2012 Genetic Loci implicated in erythroid differentiation and cell cycle regulation are associated with red blood cell traits.

rs129128 in H2BC4;H2AC6 gene and Red Blood Cell Count measurement PMID 19862010 2009 Multiple loci influence erythrocyte phenotypes in the CHARGE Consortium.